View Article

Abstract

This study outlines the preparation of a digitalis suspension for congestive heart failure (CHF) management. The method involves extracting digitalis glycosides from Digitalis purpurea leaves, followed by meticulous processing to achieve a stable suspension. The formulation's efficacy in addressing CHF symptoms is assessed, providing insights into its potential therapeutic value. This research contributes to the exploration of alternative formulations for digitalis administration in congestive heart failure patients. Digitalis, commonly derived from the foxglove plant, is a medication used to treat congestive heart failure. It helps strengthen the heart's contractions, improve circulation, and alleviate symptoms. However, it should be prescribed and monitored by a healthcare professional due to its narrow therapeutic range and potential for toxicity. Regular check-ups are essential to ensure the medication is effective and safe for the individual.

Keywords

Digitalis, CHF(congestive heart failures), Digoxin, Digitoxin,etc.

Reference

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds (1997). American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press.
  2. Nesher, M., Spolansky, U., Rosen, H. and Lichtstein, D(2007). The endogenous digitalis- like compounds -A new family of steroid hormones. Life Sci. Vol.80:2093- 2107.
  3. Shumaik GM, Wu AW, Ping AC (1988). Oleander poisoning: treatment with digoxin-specific Fab antibody fragments. Ann Emerg Med. Vol.17:732-735.
  4. Schoner, W (2002). Endogenous cardiac glycosides, a new class of steroid hormones. Eur J Biochem Vol.269:2440-2448.
  5. Schoner, W., Bauer, N., Muller-Ehmsen, J., Kramer, U., Hambarchian, N., Schwinger, R., Moeller, H., Kost, H., Weitkamp, C., Schweitzer, T., Kirch, U., Neu, H., Grunbaum, E.G (2003). Ouabain as a mammalian hormone. Ann N Y Acad Sci. Vol.986:678-684. 
  6. Schoner, W. and Scheiner-Bobis, G (2007). Endogenous and exogenous cardiac glycosides and their mechanisms of action. Am J Cardiovasc Drugs. Vol.7:173-189.
  7. Dick M, Curwin J, Tepper D (1991). Digitalis intoxication recognition and management. J Clin Pharmacol .Vol.31:444-447.
  8. Hood WB, Dans A, Guyatt GH, Jaeschke R, McMurray JJ(2004). Digitalis for treatment of congestive heart failure in patients in sinus rhythm. Cochrane Database Syst Rev (2):CD002901.
  9. Johansson S, Lindholm P, Gullbo J, Larsson R, Bohlin L, Cleason P(2001). Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells. Anticancer Drugs. Vol. 12:475-483.
  10. Lopez-Lazaro M, Palma De La Pena N, Pastor N, et al(2003). Anti-tumour activity of Digitalis purpurea L. subsp.heywoodii. Planta Med .Vol.69:701-704.
  11. Lindholm P, Gullbo J, Claeson P, et al(2002). Selective cytotoxicity evaluation in anticancer drug screening of fractionated plant extracts. J Biomol Screen . Vol.7:333-340.
  12. Lacassie E, Marquet P, Martin-Dupont S, Gaulier JM, Lachatre G(2000). A non-fatal case of intoxication with foxglove, documented by means of liquid chromatography-electrospray-mass-spectrometry. J Forensic Sci .Vol.45:1154-1158.
  13. Bagrov, A.Y., Fedorova, O.V (2005). Cardenolide and bufadienolide ligands of the sodium pump. How they work together in NaCl sensitive hypertension. Front Biosci Vol.10: 2250-2256. 
  14. Buckalew, V.M (2005). Endogenous digitalis-like factors. An historical overview. Front Biosci 1,Vol.0:2325-2334.
  15. Blaustein, M.P., Zhang, J., Chen, L., Hamilton, B.P (2006). How does salt retention raise blood pressure? Am J Physiol Regul Integr Comp Physiol; Vol.290:R514-R523.
  16. Dec GW (2003). Digoxin remains useful in the management of chronic heart failure. Med Clin North Am .Vol.87:317
  17. Tatro DS, ed. Drug Interaction Facts. St. Louis, MO(2002): Wolters Kluwer Health, Inc.; 2004. Jowett N. Foxglove poisoning. Hosp Med.Vol.63:758-759.
  18. Wickersham RM, Novak K (2004), managing eds. Drug Facts and Comparisons. St. Louis, MO: Facts and Comparisons
  19. Meyer JE (2002). The Herbalist. Hammond, IN: Hammond Book Co; 1934: 96.Belcastro PF. Digitalis: from folklore remedy to valuable drug. J Am Pharm Assoc.Vol. 42:857.

Photo
Dnyandeep Jadhav
Corresponding author

Nandkumar Shinde Collage of Pharmacy, Vaijapur, Chhatrapati Sambhajinagar.

Photo
Dipak S. Borse
Co-author

Nandkumar Shinde Collage of Pharmacy, Vaijapur, Chhatrapati Sambhajinagar.

Photo
Chaitanya G. Baviskar
Co-author

Nandkumar Shinde Collage of Pharmacy, Vaijapur, Chhatrapati Sambhajinagar.

Photo
Arvind K. Hatkar
Co-author

Dr. Babasaheb Ambedkar Tecnological University Lonere ,Raigad, Maharashtra.

Photo
Rajendra M. Kawade
Co-author

Dr. Babasaheb Ambedkar Tecnological University Lonere ,Raigad, Maharashtra.

Dnyandeep Jadhav* , Dipak Borse, Chaitanya Baviskar,  Arvind K. Hatkar, Rajendra M. Kawade.*, To Prepare Suspension Of Digitalis For Congestive Heart Failures, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 12, 714-721.https://doi.org/10.5281/zenodo.10426636

More related articles
SGLT2 Inhibitors Beyond Glycemic Control: Emerging...
Mayur Borade, Afreen Shaikh, Tejas Anarthe, Ganesh Anarthe...
Artificial Intelligence in Drug Discovery and Phar...
Siddhant Dhaware, Nishant Kamble, Amrata Suryawanshi, Kaufiya Say...
Formulation and Evaluation of Mucoadhesive Bilayer...
Annapureddy Durga Bhavani, G. Venkataramireddy...
Hydroxypropyl-?-Cyclodextrin-Complexed Sublingual Films for Anti-Vertigo Drug De...
Atharv Swami, I. D. Gonjari, Yash Yadav, Shirish Naik, Sudarshan Kamble...
Artificial Intelligence and Machine Learning in Solubility Enhancement of Poorly...
K. Ravi, Nannam. Ramabrahmam, Kodali. Ragini, K. Narendra Kumar Reddy...
Gastroretentive Floating Drug Delivery Systems of Ranitidine Hydrochloride: A Re...
Sandhya R., Suresh, Rebisha, Mathina, Bharath, Akshaya Prasad, Kenneth...
Related Articles
Film-Forming Drug Delivery Systems: Formulation, Mechanism, Evaluation and Recen...
Kavin M, Perumal T, Vijay N, Poornamirtha P, Agalya A...
Development and Preliminary Quality Profiling of a Polyherbal Shampoo Powder wit...
Dr. Gnanasekaran D, Rajesh R, Thamizhmathi V, Viknesh S, Kalaivani M, Eswar A...
A Comprehensive Review of Analytical Methods for the Determination of Semaglutid...
Dr. M. Ramakrishna, G. Jhansi, G. Hemalatha, G. Kalyani, G. Keerthana, D. Mani kumar, Dr. J. N Sures...
SGLT2 Inhibitors Beyond Glycemic Control: Emerging Therapeutic Applications, Cli...
Mayur Borade, Afreen Shaikh, Tejas Anarthe, Ganesh Anarthe...
More related articles
SGLT2 Inhibitors Beyond Glycemic Control: Emerging Therapeutic Applications, Cli...
Mayur Borade, Afreen Shaikh, Tejas Anarthe, Ganesh Anarthe...
Artificial Intelligence in Drug Discovery and Pharmacology: Applications, Advanc...
Siddhant Dhaware, Nishant Kamble, Amrata Suryawanshi, Kaufiya Sayyed...
SGLT2 Inhibitors Beyond Glycemic Control: Emerging Therapeutic Applications, Cli...
Mayur Borade, Afreen Shaikh, Tejas Anarthe, Ganesh Anarthe...
Artificial Intelligence in Drug Discovery and Pharmacology: Applications, Advanc...
Siddhant Dhaware, Nishant Kamble, Amrata Suryawanshi, Kaufiya Sayyed...