View Article

Abstract

The development of innovative medicine delivery methods is currently generating renewed interest. These innovative drug delivery technologies also include vesicular drug delivery systems. The permeability of the skin, or TDDS, is extremely impermeable to macromolecules and hydrophilic medicines but permeable to small molecules and lipophilic medications. Recent methods have led to the creation of two vesicular carriers: ethosomes and transferosomes, which are incredibly elastic lipid-based vesicles. Recently developed transferosomes are able to deliver both high and low molecular weight medications transdermally. This has a number of potential benefits over conventional methods, including avoiding first pass metabolism, extending activity predictability, limiting negative side effects, and utilizing medicines with short half-lives.

Keywords

Transferosomes, Novel Drug Delivery System, Targeted drug delivery, transdermal route

Reference

  1. Y. Dastagiri Reddy et al., JIPBS, Vol 2 (2), , 2015
  2.  Journal of Drug Delivery & Therapeutics. 2023; 13(2):126-131 Available online on 15.02.2023 at http://jddtonline.info
  3. Int. J. Adv. Res. 11(04), 877-881
  4. Das B, Nayak AK, Mallick S. Transferosomes: a novel nanovesicular approach for drug delivery. InSystems of Nanovesicular Drug Delivery 2022 Jan 1 (pp. 103-114). Academic Press. https://doi.org/10.1016/B978-0-323-91864-0.00022-X
  5. Chhotalal kalpesh Vesicular Drug Delivery System: A Novel approach September 2014
  6. Irfan M, Verma S, Ram A. Preparation and characterization of ibuprofen loaded transferosomes as a novel carrier for transdermal drug delivery system. Asian j Pharm. clin resear. 2012. (162-165).
  7. Opatha SA, Titapiwatanakun V, Chutoprapat R. Transfersomes: A promising nanoencapsulation technique for transdermal drug delivery. Pharmaceutics. 2020 Sep 9; 12(9):855. https://doi.org/10.3390/pharmaceutics12090855
  8. Trommer H, Neubert RHH: Overcoming the stratum corneum. The modulation of skin penetration. A review, Skin Pharmacology and Physiology. 2006. (106-121). 
  9. El Zaafarany GM, Awad GAS, Holayel SM, Mortada ND. Role of edge activators and surface charge in developing ultra deformable vesicles with enhanced skin delivery. Int J Pharm. 2010. (164-172).
  10. Cevc G, Grbauer D, Schatzlein A, Blume G. Ultraflexible vesicles, transferosomes, have an extremely low pore penetration resistance ant transport therapeutic amounts of insulin across the intact mammalian skin. Biochem Biophys Act. 1998. (201-215) 
  11. El-Maghraby GM, Williams AC. Vesicular systems for delivering conventional small organic molecules and larger macromolecules to and through human skin. Expert Opin Drug Deliv. 2009. (149- 163)
  12.  Walve JR, Bakliwal SR, Rane BR, Pawar SP. Transferosomes: A surrogated carrier for transdermal drug delivery system. Int J App Bio Pharm Tech. 2011.(201-214) 
  13. Cevc G, Blume G. Lipid vesicles penetrate into intact skin owing to transdermal osmotic gradient and hydration force. Biochem Biophys Act 1992.(226-332). 
  14. Jain NK. Advances in Controlled and Novel Drug Delivery. CBS Publishers and Distributers First edition2001. New Delhi.(426-451). 
  15. Paul, A, Cevec G. Non-invasive Administration of Protein Antigens. Epicutaneous with Bovin Serum Albumine, Vaccine Research, 1998.(145- 164). 
  16. Modi CD, Bharadia PD. “Transferosomes: New Dominants for Transdermal Drug Delivery”. Am. J.PharmTech Res., 2012.(71-91) 
  17. Prajapati ST, Patel CG, Patel CN. “Transferosomes: A Vesicular Carrier System for Transdermal Drug Delivery”. Asian Journal of Biochemical and Pharmaceutical Research, 2011.(507- 524). 
  18. Kombath RV, Minimal SK, Sockalingam A, Subadhra S, Parre S, Reddy TR, David B. “Critical issues related to transferosomes – novel Vesicular system”. Act Sci.(67-82)
  19. Walve JR, Bakliwal SR, Rane BR, Pawar SP. “Transferosomes: A surrogated carrier for transdermal drug delivery system”. International Journal of Applied Biology and Pharmaceutical Technology, 2011.Pol. Technol. Aliment, 2012.(204-213)
  20. Chaurasiya P, Ganju E, Upmanyu N, Ray SK, Jain P. Transfersomes: a novel technique for transdermal drug delivery. Journal of drug delivery and therapeutics. 2019 Jan 15; 9(1):279-85. https://doi.org/10.22270/jddt.v9i1.2198
  21. Jain AK, Kumar F. Transfersomes: Ultradeformable vesicles for transdermal drug delivery. Asian J. Biomater. Res. 2017; 3:1-3. 
  22. Rajkumar J, Kumar AS, Shahnawaz GJ, Sushmitha A. Recent Update on Transferosomes as Transdermal Drug Delivery System. J Pharmacy and Drug Innovations. 2021 Dec 10; 3(2).
  23. Rajan R, Jose S, Mukund VB, Vasudevan DT. Transferosomes-A vesicular transdermal delivery system for enhanced drug permeation. Journal of advanced pharmaceutical Technology & Research. 2011 Jul; 2(3):138 https://doi.org/10.4103/2231- 4040.85524
  24. Rai S, Pandey V, Rai G. Transfersomes as versatile and flexible nanovesicular carriers in skin cancer therapy: the state of the art. Nano Reviews & Experiments 8 (1):1325708 https://doi.org/10.1080/20022727.2017.1325708
  25. Sheo DM, Shweta A, Ram CD, Ghanshyam M, Girish K, Sunil KP, Transfersomes-A novel vesicular carrier for enhanced transdermal delivery of stavudine: Development, characterization and performance evaluation. J Scientific Speculations and Res 2010; 1(1):30-36
  26. Podili C, Firoz S. A review on transferosomes for transdermal drug delivery. J. Glob. Trends Pharm. Sci. 2014; 5(4):2118-27.
  27. Patel R, Development and characterization of curcumin loaded transfersome for transdermal delivery. J. Pharm. Sci. Res. 1 (4).2009;71-0
  28. Jain S, Sapee R, Jain NK, Ultraflexible lipid vesicles for effective transdermal delivery of norgesterol. In: Proceedings of 25th Conference of C.R.S.1998;USA32-5. 
  29. Hafer C, Goble R, Deering P, Lehmer A., Breut J, Formulation of interleukin-2 and interferon-a containing ultra deformable carrier for potential transdermal application. Anticancer Res. 19 (2c).1999; 1505-12.
  30. Paul A, Cevec G, Non-invasive administration of protein antigens, epicutaneous with bovin serum albumin. Vaccine Res.1998; 4: 145-164. 
  31. Paul A, Cevec G, BachhavatBK,Transdermal immunization with large proteins by means of ultra deformable drug carriers. Eur. J. Immunol. 1995;25: 3551-24. 
  32. Planas ME, Gonzalez P, Rodriguez S, Sanchez G, Cevc G, Non invasive percutaneous induction of topical analgesia by a new type of drug carrier and prolongation of local paini insensitivity by anesthetic liposomes. Anesthia Analog.1992; 615-21

Photo
Shreya Lokhande
Corresponding author

Gadge Nagar Amravti (Maharashtra)444601.

Photo
Monika Jadhao
Co-author

Gadge Nagar Amravti (Maharashtra)444601.

Shreya Lokhande*, Monika Jadhao, Transferosomes: A Novel Approach To Drug Delivery, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 279-287. https://doi.org/10.5281/zenodo.8344306

More related articles
A Review on Nanomedicine in Oral Healthcare: Beyon...
Nehere Ishika , Swapnil Kale, Maid Dipali , Sanghavi Kanchi , Dar...
Artificial Intelligence and Machine Learning in Ad...
Mohamed Adil N, Jayalakshmi Venugopal, Srinivas S.K. , Renupriya ...
Formulation And Evaluation Of A De-Tan Face Wash T...
Kumbhar Bhaganna Gundappa , G. B. Gajeli, Giram Aarti Kashinath ,...
Drug Use Evaluation (DUE) of Antiplatelet agents in a Tertiary Care Hospital : ...
Arati Konde, Manoj Pisure, Trupti Tuse, Sudha Nerlekar, Shrawani Rathor, Snehal Godase...
Comparative Evaluation of Antimicrobial and Anti-inflammatory Activity of Jatrop...
Bhuvana Ezhil Rohini R, Vaishnavi B, Ragu Semaraj T, Kishore Kumar R, Janani R, Abinaya V, Sujatha ...
Related Articles
Formulation And Evaluation O Herbal Neem Face Wash Powder...
Bansode Disha, Hemant H.Gangurde, Hemant Gangurde, Somnath Davkhar, Bandgar Sakshi...
Herbal Extract- Based Peel-Off Face Mask Gels for Skin Rejuvenation and Anti-Age...
Dhanyashree K, Rakshith K J, Chaithra M P, Hemavathi N...
Nano Herbal Transferosomal Serum –A Dual Functional Approach For Anti-Aging An...
Rubicashree S, Anju K.P., Murali R, Srinidhi C, Chaya P...
Pharmacological Innovations in Alzheimer's Disease: Recent Progress and Future P...
Rajratan Thorat, Rajani Athawale, Vijay Kadam, Madhuri Dhure, Prerana Bambale...
A Review on Nanomedicine in Oral Healthcare: Beyond Toothpaste and Mouthwash...
Nehere Ishika , Swapnil Kale, Maid Dipali , Sanghavi Kanchi , Darode Tejaswi , Jadhav Shraddha ...
More related articles
A Review on Nanomedicine in Oral Healthcare: Beyond Toothpaste and Mouthwash...
Nehere Ishika , Swapnil Kale, Maid Dipali , Sanghavi Kanchi , Darode Tejaswi , Jadhav Shraddha ...
Artificial Intelligence and Machine Learning in Adverse Drug Events and Precisio...
Mohamed Adil N, Jayalakshmi Venugopal, Srinivas S.K. , Renupriya J...
Formulation And Evaluation Of A De-Tan Face Wash Tablet...
Kumbhar Bhaganna Gundappa , G. B. Gajeli, Giram Aarti Kashinath , Alamad Abhishek Lokanna, Narayane ...
A Review on Nanomedicine in Oral Healthcare: Beyond Toothpaste and Mouthwash...
Nehere Ishika , Swapnil Kale, Maid Dipali , Sanghavi Kanchi , Darode Tejaswi , Jadhav Shraddha ...
Artificial Intelligence and Machine Learning in Adverse Drug Events and Precisio...
Mohamed Adil N, Jayalakshmi Venugopal, Srinivas S.K. , Renupriya J...
Formulation And Evaluation Of A De-Tan Face Wash Tablet...
Kumbhar Bhaganna Gundappa , G. B. Gajeli, Giram Aarti Kashinath , Alamad Abhishek Lokanna, Narayane ...