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Abstract

It is tetracycline antibiotic. Tigecycline is a new intravenous broad spectrum antibiotic with activity against many drug-resistant organisms. Tigecycline is the first drug in the glycycline class of antibiotic. It is derivative of minocycline .It is developed in respond to growing rate of antibiotic resistant bacteria such as Staphylococcus aureus, Acinetobacter baumannii, and E. coli. Tigecycline has a broad spectrum of activity, including activity against drug-resistant gram-positive organisms. The dose of Tigecycline 50mg intravenously every 12 hours after a 100 mg loading dose. Tigecycline has historically been administered intravenously because it exhibits generally poor bioavaibility when given orally. Tigecycline is currently manufactured as a lyophilized powder. Due to the propensity for tigecycline to degrade, these powders are prepared under low-oxygen and low-temperature conditions in order to minimize degradation. Such processing is expensive because it requires special equipment and handling. Tigecycline is used to treat different kinds of bacterial infections, including complicated skin and structure infections, complicated intra-abdominal infections and community-acquired bacterial pneumonia.

Keywords

Tigecycline, Lyophillization

Reference

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Photo
Sakshi D. Surade
Corresponding author

S.N.D COLLEGE OF PHARMACY

Photo
Vikas S. Shinde
Co-author

S.N.D College Of Pharmacy

Sakshi D. Surade, Vikas S. Shinde, Evaluation Parameters Of Tigecycline : Tetracycline Antibiotic, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 1, 818-825. https://doi.org/10.5281/zenodo.10588903

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