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  • Structure Biosynthesis And Examination Of Bioactive Small Molecule

  • 1Student Kishori college of pharmacy Beed
    2Assistant professor Kishori college of pharmacy Beed
    3Principal  Kishori college of pharmacy Beed
     

Abstract

Collaborative research projects between chemists, biologists, and medical scientists have inevitably produced many useful drugs, biosensors, and medical instrumentation. Organic chemistry lies at the heart of drug discovery and development. The current range of organic synthetic methodologies allows for the construction of unlimited libraries of small organic molecules for drug screening. In translational research projects, we have focused on the discovery of lead compounds for three major diseases: Alzheimer disease, breast cancer, and viral infections. In the Alzheimer disease project, we have taken a rational-design, approach and synthesized a new class of tricyclic pyrone compounds that preserve memory and motor functions in amyloid precursor protein /presenilin-1 mice. TP's could protect neuronal death through several possible mechanisms, including their ability to inhibit the formation of both intraneuronal and extracellular amyloid B aggregates, to increase cholesterol efflux, to restore axonal trafficking, and to enhance long-term potentiation and restored LTP following treatment with amyloid B Oligomers.

Keywords

Bioactive Small Molecule, Structure Biosynthesis.

Reference

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Photo
Pravin D. Chand
Corresponding author

Student Kishori college of pharmacy Beed

Photo
A. S. sanap
Co-author

Assistant professor Kishori college of pharmacy Beed

Photo
Prachi P. Udapurkar
Co-author

Principal Kishori college of pharmacy Beed

Pravin D. Chand, Prachi P. Udapurkar, A. S. Sanap, Structure Biosynthesis And Examination Of Bioactive Small Molecule, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 139-144. https://doi.org/10.5281/zenodo.10625232

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