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Shri Ganapati institute of pharmaceutical science and research, Tembhurni
The drug action can be improved by developing the new drug delivery system, such as the mucoadhesive drug delivery system. These systems remain in close contact with absorption tissue the mucus membrane, releasing the drug action site leading to a bioavailability rise and both local and systemic effect . The mucoadhesion is currently explained by 5 theories: Wetting, Electrostatic, Diffusion, Adsorption, Fracture. The polymers used for the formulation of mucoadhesive drug delivery system are PAA (polyacrylamide acid),chitosan, collagen, gelatin and newer second-generation polymers. The process of complex one that includes process such as wetting, adsorption and interpretation of polymer chain. The mucoadhesive ability of a dosage form is depend upon the variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. Mucoadhesive system have found wide use throughout many mucosal covered organelles for active ingredients delivery for local or systemic effect. The administration of the drug by the buccal route has several advantages over per oral administration such as quick action improved the patient compliance particularly with the paediatrics and geriatric patient. It includes detail information about mucus, advantages, disadvantages of drug delivery system, mechanism , factors affecting on mucoadhesive drug delivery, mucoadhesive dosage form, mucoadhesive polymer and application of mucoadhesive drug delivery system.
Rutuja S. Pawar*, Sukumar M. Lande, Rupali R. Bendgude, Review: A mucoadhesive drug delivery system, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 829-835. https://doi.org/10.5281/zenodo.10435594
10.5281/zenodo.10435594